Isothermal titration calorimetry (ITC) study of natural cyclodextrins inclusion complexes with tropane alkaloids
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چکیده
منابع مشابه
Quick Start: Isothermal Titration Calorimetry (ITC)
Isothermal titration calorimetry (ITC) is a technique used to determine the thermodynamic properties of a chemical or physical equilibria. While the most abundant applications lie in the field of biochemical characterization, its use has increased in other fields because of minimal sample and buffer restrictions. The foundation of this technique is based on the simple measurement of heat, q. Be...
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β-Cyclodextrin (β-CD) is studied as a carrier of the drug mianserin (MIA). β-CD with MIA adducts with 1 : 1 and 2 : 1 stoichiometry are investigated in vacuo and in water using quantum chemical methods: PM6 and B3LYP/6-31G(d,p). An effect of the dispersion correction GD2 and the basis set superposition error on the complexation energies is also evaluated. Additionally, the interaction between M...
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The solubility of trihexyphenidyl (Thp) was improved by its combination with β-cyclodextrin (β-CD) and modified β-CDs. The solubility of Thp was found to be increased in the presence of β-CD, hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin (Me-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD). In particular, the solubility of Thp in conjunction with SBE-β-CD was increased by a f...
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ژورنال
عنوان ژورنال: Journal of Thermal Analysis and Calorimetry
سال: 2015
ISSN: 1388-6150,1588-2926
DOI: 10.1007/s10973-015-4658-1